Veterinary medicine

APPLICATIONS AND BENEFITS
IN VETERINARY MEDICINE

PetCellpen® BENEFITS

For the veterinarian

  • Cutting-edge technology for everyday use
  • No consumables or disposables
  • Wireless and lightweight (250g)
  • Reduced use of antibiotics
  • Results from the very first session
  • Any species, body area and size
  • No personal protective equipment required
  • Stand-alone or adjunctive therapy to the clinical protocol
  • No clipping or post-clipping cleaning
  • Short and calm sessions
  • Can be used by veterinarians and veterinary nurses
  • Easy handling and application

For the patient

  • Painless, minimal handling
  • No adverse effects
  • Treatment is well tolerated
  • Reduces the consumption of pharmaceutical products
  • Faster healing process
  • Combats resistant infections
  • Can be used on ulcerated tumours
  • Extensive list of indications
  • Effective in multi-resistant infections
  • Depth of action of more than 1cm
This device is intended for use only by veterinary professionals for the treatment of small animals and horses.

Applications

WOUND MANAGEMENT

Indications
  • Abrasions
  • Bites
  • Non-healing wounds
  • Burns
  • Pressure ulcers
  • Scars and keloids
  • Healing by second intention
  • Ulcerated tumours
See clinical cases
Cold plasma demonstrates a number of effects that promote the healing process. Plasma treatment with the PetCellpen® accelerates and improves the quality of wound healing in all its phases. After a first treatment, a positive effect on wound regeneration can already be seen, even in wounds where the healing process had reached a standstill.
See clinical cases
Scars
Scars
Healing complications
Healing complications
Dehiscence
Dehiscence
Bites
Bites
Periodontitis
Periodontitis
Polytrauma
Polytrauma
Pressure ulcers
Pressure ulcers

DERMATOLOGY

Indications
  • Abscesses
  • Hotspots
  • Furunculosis
  • Fistulas
  • Pyodermas
  • Trichophytosis
  • Otitis externa
  • Vasculopathies
See clinical cases
PetCellpen® can be used as a stand-alone therapy and as an adjunctive treatment for various infectious skin diseases without generating resistance due to its broad-spectrum antimicrobial effect. Skin infections with multi-resistant microorganisms can be practically treated with the help of cold plasma. In multifactorial diseases, inflammation caused by allergic aetiopathogenesis is modulated, itching is reduced and healing is improved.  
See clinical cases
Fistulas
Fistulas
Anal fistulas
Anal fistulas
Hotspot
Hotspot
Exudative pyoderma
Exudative pyoderma
Papillomavirus-induced focal plaque
Papillomavirus-induced focal plaque
Eosinophilic pododermatitis
Eosinophilic pododermatitis
Furunculosis
Furunculosis

Musculoskeletal and NEUROMUSCULAR

Indications
  • Muscle tension and spasms
  • Myofascial pain
  • Arthritis, tendinitis
  • Strains
  • Spondylosis
  • Compressive spinal cord pathologies
  • Post-surgical rehabilitation
  • Limber tail syndrome
  • Myositis
  • Neuropathic pain
See clinical cases
PetCellpen® modulates inflammation in acute ligament, muscle and tendon injuries that can resolve faster through direct cell stimulation and stimulation of blood flow. PetCellpen® also includes a special automatic function for desensitization. In chronic and degenerative diseases of the neuromuscular system, this form of therapy has anti-inflammatory and pain-inhibiting properties, making the application of CAP useful in cases of neuropathic pain and myositis.  
See clinical cases
Dorso-caudal pain
Dorso-caudal pain
Spondylosis
Spondylosis
Limber tail syndrome
Limber tail syndrome
All clinical cases

Download the 44 successful clinical cases in companion animals.

Download (PDF)
Therapeutic guide

Detailed instructions for use and according to therapeutic application.

Download (PDF)
Antimicrobial effects: Bacteria
  • Brun P, Bernabè G, Marchiori C, Scarpa M, Zuin M, Cavazzana R, Zaniol B, Martines E. Antibacterial efficacy and mechanisms of action of low power atmospheric pressure cold plasma: membrane permeability, biofilm penetra­tion and antimicrobial sensitization. J Appl Microbiol. 2018 Aug;125(2):398-408. PMID: 29655267. doi: 10.1111/jam.13780
  • Haghighi L, Azizi A, Vatanpour M, Ramezani G. Antibacterial Efficacy of Cold Atmospheric Plasma, Photodynamic Therapy with Two Photosensitizers, and Diode Laser on Primary Mandibular Second Molar Root Canals Infec­ted with Enterococcus faecalis: An in Vitro Study. Int J Dent. 2023 Apr 21:2023:5514829. PMID: 37123349. doi: 10.1155/2023/5514829
Antimicrobial effects: Viruses
  • Alekseev O, Donovan K, Limonnik V, Azizkhan-Clifford J. Nonthermal Dielectric Barrier Discharge (DBD) Plasma Su­ppresses Herpes Simplex Virus Type 1 (HSV-1) Replication in Corneal Epithelium. Transl Vis Sci Technol. 2014 Mar 27;3(2):2. PMID: 24757592. doi: 10.10.1167/tvst.3.2.2
  • Bunz O, Mese K, Zhang W, Piwowarczyk A, Ehrhardt A. Effect of cold atmospheric plasma (CAP) on human adenovi­ruses is adenovirus type-dependent. PLoS One. 2018 Oct 26;13 (10):e0202352. PMID: 30365500. doi: 10.1371/jour­nal.pone.0202352
  • Aboubakr HA, Mor SK, Higgins LA, Armien A, Youssef MM, Bruggeman PJ, Goyal SM. Cold argon-oxygen plasma species oxidize and disintegrate capsid protein of feline calicivirus. PLoS One. 2018 Mar 22;13(3):e0194618. PMID: 29566061. doi: 10.1371/journal.pone.0194618
Antimicrobial effects: Fungi
  • Lee T-H, Hyun J-E, Kang Y-H, Baek S-J, Hwang C-Y. In vitro antifungal activity of cold atmospheric microwave plasma and synergistic activity against Malassezia pachydermatis when combined with chlorhexidine gluconate. Vet Med Sci. 2022 Mar;8(2):524-529. PMID: 35089639. doi: 10.1002/vms3.719
  • Šimončicová J, Kaliňáková B, Medvecká V, Lakatoš B, Kryštofová S, Hoppanová L, Palušková V, Hudecová D, Ďurina P, Zahoranová A. Cold plasma treatment triggers antioxidative defense system and induces changes in hyphal surface and subcellular structures of Aspergillus flavus. Appl Microbiol Biotechnol. 2018 Aug;102(15):6647-6658. PMID: 29858953. doi: 10.1007/s00253-018-9118-y
  • Gnat S, Lagowski D, Dylag M, Zielinski J, Studzinski M, Nowakiewicz A. Cold atmospheric pressure plasma (CAPP) as a new alternative treatment method for onychomycosis caused by Trichophyton verrucosum: in vitro studies. 2021 Dec;49(6):1233-1240. PMID: 34499324. doi: 10.1007/s15010-021-01691-w
Antimicrobial effects: Parasites
  • Ten Bosch L, Habedank B, Siebert D, Mrotzek J, Viöl W. Cold Atmospheric Pressure Plasma Comb – A Physical Approach for Pediculosis Treatment. Int J Environ Res Public Health 2018 Dec 21;16(1):19. PMID: 30577656. doi: 10.3390/ijerph16010019
  • Daeschlein G, Scholz S, Arnold A, von Woedtke T, Kindel E, Niggmeier M, Weltmann K-D, Jünger M. In Vitro Activity of Atmospheric Pressure Plasma Jet (APPJ) Plasma Against Clinical Isolates of Demodex Folliculorum. IEEE Transac­tions on Plasma Science, Vol. 38, No. 10, October 2010. doi: 10.1109/TPS.2010.2061870
Neovascularisation and angiogenesis
  • Schmidt A, Liebelt G, Striesow J, Freund E, von Woedtke T, Wende K, Bekeschus S. The molecular and physiologi­cal consequences of cold plasma treatment in murine skin and its barrier function. Free Radic Biol Med. 2020 Dec: 161:32-49. PMID: 33011275. doi: 10.1016/j.freeradbiomed.2020.09.026
  • Chatraie M, Torkaman G, Khani M, Salehi H, Shokri B. In vivo study of non-invasive effects of non-thermal plasma in pressure ulcer treatment. Sci Rep. 2018 Apr 4;8(1):5621. PMID: 29618775. doi: 10.1038/s41598-018-24049-z
  • Schmidt A, Niessner F, von Woedtke Th, Bekeschus S. Hyperspectral Imaging of Wounds Reveals Augmented Tissue Oxygenation Following Cold Physical Plasma Treatment in Vivo. IEEE TRANSACTIONS ON RADIATION AND PLASMA MEDICAL SCIENCES, VOL. 5, NO. 3, MAY 2021
  • T. von Woedtke, A. Schmidt, S. Bekeschus, K. Wende, K.D. Weltmann, Plasma medicine: a field of applied redox biology, Vivo 33 (2019) 1011–1026, doi: 10.21873/invivo.11570
Modulation of inflammatory cytokines
  • Schmidt A, von Woedtke T, Vollmar B, Hasse S, Bekeschus S. Nrf2 signaling and inflammation are key events in physical plasma-spurred wound healing. Theranostics. 2019 Jan 30;9(4):1066-1084. PMID: 30867816. doi: 10.7150/thno.29754
  • Ding C, Huang P, Feng L, Jin T, Zhou Y, He Y, Wu Z, Liu Y. Immediate intervention effect of dielectric barrier discharge on acute inflammation in rabbit’s ear wound, AIP Advances 10. 2020, 025008. doi: 10.1063/1.5139953
Cellular apoptosis
  • Haertel B, von Woedtke T, Weltmann K-D, Lindequist U. Non-thermal atmosperic-pressure plasma possible application in wound healing. Biomol Ther (Seoul). 2014 Nov;22(6):477-90. PMID: 25489414. doi: 10.4062/biomolther.2014.105
  • Gay-Mimbrera J, Garcia MC, Isla-Tejera B, Rodero-Serrano A, Garcia-Nieto AV, Ruano J. Clinical and Biological Princi­ples of Cold Atmospheric Plasma Application in Skin Cancer. Adv Ther. 2016 Jun;33(6):894-909. PMID: 27142848. doi: 10.1007/s12325-016-0338-1
Nerve regeneration
  • Lee S-T, Jang Y-S, Kim U-K, Kim H-J, Ryu M-H, Kim G-C, Hwang D-S. Non-thermal plasma application enhances the recovery of transected sciatic nerves in rats. Exp Biol Med (Maywood). 2021 Jun;246(11):1287-1296. PMID: 33653158. doi: 10.1177/1535370221996655
  • Ding C, Ni L, Liu Q, et al. Cold air plasma improving rheumatoid arthritis via mitochondrial apoptosis pathway. Bioeng Transl Med. 2023;8(1):e10366. doi:10.1002/btm2.10366
  • Faramarzi F, Zafari P, Alimohammadi M, et al. Inhibitory Effects of Cold Atmospheric Plasma on Inflammation and Tu­mor‑Like Feature of Fibroblast‑Like Syn
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